IBgen IVF. A genetic test of ovarian reserve

An analysis of the genes linked to ovarian reserve can help us reach a diagnosis, enable us to design personalised courses of treatment for patients and determine which medication is most appropriate in each case (pharmacogenetics).

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It is a ground-breaking genetic test of ovarian function that provides important information for solving medical cases involving women who wish to become mothers but who have a limited number of oocytes (ova). It allows the medical team to design a personalised course of treatment for the patient and determine which type of medication is most appropriate (pharmacogenetics) for achieving a bigger and better ovarian response during assisted reproduction treatment.  In other words, improving the patient’s chances of getting pregnant.

What is the IBgen IVF test?

It is a ground-breaking genetic test of ovarian function that provides important information for solving medical cases involving women who wish to become mothers but who have a limited number of oocytes (ova).

IBgen IVF includes an analysis of gene polymorphisms: FSHR, IL-11, POLG and AR.

It allows the medical team to design a personalised course of treatment for the patient and determine which type of medication is most appropriate (pharmacogenetics) for achieving a bigger and better ovarian response during assisted reproduction treatment.  In other words, improving the patient’s chances of getting pregnant.

How is the IBgen IVF test performed?

A sample of saliva or blood taken from the patient is the necessary biological material for the laboratory at IB BIOTECH to extract sufficient DNA for studying the genetic variants that allow us to understand a patient's ovarian response before beginning treatment. This helps us to define the most appropriate course of medication in order to obtain the highest possible number of oocytes and improve the patient’s prognosis.

Advantages of the IBgen IVF test

  • It identifies the cause of poor ovarian response and provides a diagnosis, as well as the most appropriate course of treatment.
  • It increases the efficiency of assisted reproduction treatment because it is able to give a reliable indication of the most appropriate medication and dose for the patient's genetics. This optimises her ovaries’ response.
  • It removes the emotional stress that the patient feels in relation to the reproduction issue because it provides an in-depth understanding of the pathology.

Who is the IBgen IVF test recommended for?

  • Patients who wish to understand the reason for their poor ovarian response and obtain a therapeutic programme that has been adapted to their needs.
  • Patients who are preparing themselves for in vitro fertilisation treatment and who wish to take medication that is suited to their genetic make-up.
  • Patients who wish to plan maternity and, based on personal preference or family background, wish to understand the chances of them having poor ovarian response in the future.

The scientific basis for IBgen IVF:

In over 4 years of researchour team of scientists has analysed and identified the genes involved in ovarian response. A second phase of this research involved studying the impact of the genotype on ovarian response depending on the type of medication that is administered. This was the first time in the world that this had been done and over 300 patients and 400 ovarian stimulation cycles were analysed.

The conclusions of the study, as presented at the most significant scientific congresses in the field and published in prestigious medical journals, gave an in-depth understanding of the most appropriate medication and dose for each genotype. Applying this knowledge is a huge advantage for patients with poor ovarian response because they are able to obtain a larger number of ova. As such, they are able to have children using their own gametes and can avoid using eggs donated by another woman.