A study performed by Instituto Bernabeu assesses whether it is preferable to perform freezing or fresh transfer following embryo biopsy

Research performed by Instituto Bernabeu has looked into whether fresh transfer or deferred transfer through cryopreservation followed by defrosting is the best strategy for carrying out pre-implantation genetic diagnosis for aneuploidies (PGT-A).

The research’s main author, biologist Jorge Ten, points out that biopsies are currently carried out in blastocyst stage (embryo on day five or six) and a chromosomal analysis is performed using array CGH or next-generation sequencing (NGS) techniques. The research work, which has been submitted to the Spanish Fertility Society (SEF), compares clinical results in PGT-A cycles using the two strategies over a three-year period.

The Instituto Bernabeu research concludes that both techniques are valid. A total number of 420 fresh transfers and 269 cryotransfers of euploidy embryos were performed and the number of successful pregnancies were similar in both fresh transfer and in cryopreservation. 

¿Cuál es la mejor estrategia para realizar un ciclo de diagnóstico genético preimplantacional para aneuploidías? Ten, J.; Ortiz, JA.; Guerrero, J.; Rodríguez-Arnedo, A.; Lledó, B.; Bernabeu, A.; Ll. Aparicio, J.; Bernabeu,R.